Clinical Publications

Alzheimer's Research.

Accelerating the path to reversal through clinical genomics and system-level intervention planning. Validated by 9 accepted papers in 2026.

9 Accepted Alzheimer Papers 2 Oral Presentations 5 Major Venues Genomics & Foundation Models, 2026
Breakthrough Paper

The Foundational Discovery

The peer-reviewed breakthrough that inspired The Reversal Initiative — demonstrating the potential for pathology reversal in vivo.

Cell Reports Medicine · January 2026

"NAD+ Restoration and BBB Integrity Repair Reverses Advanced Alzheimer's in Mice"

Journal: Cell Reports Medicine  ·  Published: January 2026  ·  Model: 5xFAD (aggressive AD model)
Authors: Pieper Lab, Case Western Reserve / Harrington
DOI: 10.1016/j.xcrm.2025.102535
Note: AIXC provided computational support for this research, focusing on target identification and molecular docking validation.

Key Findings

Reversed amyloid plaque accumulation
Resolved tau neurofibrillary tangles
Repaired blood-brain barrier integrity
Restored cognitive function in vivo
Alzheimer's Clinical Genomics

2026 Research Highlights

Recent research advancing clinical intervention planning for Alzheimer's disease reversal.

Genomics & Foundation Models
Hierarchical Disease-State Generators for Neurodegenerative Genomics: A Clinical Benchmark for Intervention Modeling
David Scott Lewis, Enrique Zueco
Alzheimer'sMulti-omics
Computational Systems Biology ORAL
Validated Models for Multi-Scale Alzheimer's Disease Progression and Pharmacologic Reversal Trajectories
David Scott Lewis, Enrique Zueco
Alzheimer'sReversal Trajectories
Neuro-Symbolic Reasoning
Active Causal Hypothesis Testing for NAD+-Centered Alzheimer's Disease Reversal
David Scott Lewis, Enrique Zueco
Alzheimer'sNAD+ Targets
Computational Systems Biology
Optimizing Alzheimer's Disease Treatment Timing and Dosing via Multi-Scale Feedback Models
David Scott Lewis, Enrique Zueco
Alzheimer'sDosing Optimization
Neuro-Symbolic Reasoning ORAL
Autoformalizing Biomedical Text into Verified Knowledge Graphs for Alzheimer's Disease
David Scott Lewis, Enrique Zueco
Alzheimer'sKnowledge Extraction
Genomics & Foundation Models
Closing the Genomic Experimental Loop for Alzheimer's Disease Reversal via Agentic Discovery
David Scott Lewis, Enrique Zueco
Alzheimer'sExperimental Design
Genomics & Foundation Models
Uncertainty-Aware Biomarker Discovery for Alzheimer's Reversal: Bridging Research Models and Human Translation
David Scott Lewis, Enrique Zueco
Alzheimer'sTranslational Biomarkers

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